Yang, Yang (2016) Expedient Synthesis of 4-Aryl Quinazoline Analogues via Direct Nucleophilic Arylation of 2-Chloroquinazoline. Synthesis, 48 (14). pp. 2255-2262. ISSN 0039-7881

Abstract

A practical approach was developed for the synthesis of 4-aryl quinazoline compounds via a one-pot nucleophilic arylation of 2-chloro-quinazoline with aryl lithiums generated in situ, followed by ring oxidation. The obtained adducts 2-chloro 4-aryl quinazolines were further demonstrated as versatile intermediates that undergo a variety of synthetic transformations to provide functionalized quinazoline compounds. The arylation intermediate dihydroquinazoline was also elaborated to novel tricyclic compound dihydroimidazo[2,1-b]quinazolinone.

Item Type:	Article
Keywords:	Quinazoline; Nucleophilic Arylation;
Date Deposited:	12 Oct 2016 00:45
Last Modified:	12 Oct 2016 00:45
URI:	https://oak.novartis.com/id/eprint/27855