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Correlation of BK Virus Neutralizing Serostatus with the Incidence of BK Viremia in Kidney Transplant Recipients

Abend, Johanna and Sathe, Atul and Changala, Marguerite and Casey, Fergal and Kistler, Amy and Chandran, Sindhu and Howard, Abigail and Wojciechowski, David (2016) Correlation of BK Virus Neutralizing Serostatus with the Incidence of BK Viremia in Kidney Transplant Recipients. Transplantation. p. 1. ISSN 0041-1337

Abstract

Background: BK virus-associated nephropathy (BKVAN) is the second leading cause of graft loss in kidney transplant recipients. Due to the high prevalence of persistent infection with BK virus (BKV) in the general population, it is possible that either the transplant recipient or donor may act as the source of virus resulting in viruria and viremia. While several studies suggest a correlation between donor-recipient serostatus and the development of BK viremia, specific risk factors for BKV-related complications in the transplant setting remain to be established.
Methods: We retrospectively determined the pre-transplant BKV neutralizing serostatus of 116 donor (D)-recipient (R) pairs using infectious BKV neutralization assays with representatives from the four major viral serotypes. The neutralizing serostatus of donors and recipients was then correlated with the incidence of BK viremia during the first year post-transplantation.
Results: There were no significant differences in baseline demographics or transplant data among the four neutralizing serostatus groups, with the exception of calculated panel reactive antibody (cPRA) which was lowest in the D+/R- group. Recipients of kidneys from donors with significant serum neutralizing activity (D+) had elevated risk for BK viremia, regardless of recipient serostatus (D+ versus D-: OR 5.0 [CI 1.9-12.7]; P=0.0008). Furthermore, donor-recipient pairs with D+/R- neutralizing serostatus had the greatest risk for BK viremia (OR 4.9 [CI 1.7-14.6]; P=0.004).

Item Type: Article
Date Deposited: 08 Jun 2016 23:45
Last Modified: 08 Jun 2016 23:45
URI: https://oak.novartis.com/id/eprint/27769

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