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GPR91 deletion enhances mast cell activation while preventing arthritic disease

Rubic-Schneider, Tina and Carballido-Perrig, Nicole and Regairaz Kalenga Kapiamba, Camille and Raad, Layla and Jost, Sandra and Christen, Brigitte and Wieczorek, Grazyna and Kreutzer, Robert and Dawson King, Janet and Lametschwandner, Guenther and Littlewood-Evans, Amanda and Carballido, Jose (2016) GPR91 deletion enhances mast cell activation while preventing arthritic disease. Allergy, DO - (DO - ). pp. 1-9. ISSN 1398-9995

Abstract

While searching for a role of succinate on skin inflammation we discovered that its specific receptor, GPR91/SUCNR1 is also expressed by mast cells. Sucnr1-/- mast cells displayed enhanced reactivity to allergen-IgE crosslinking. However, such responses were acute in nature and did not contribute to the enhancement of asthma or arthritis and, we therefore suggest, they are due to alterations during mast cell differentiation. The fact that sucnr1-/- mice were protected from arthritis development, using two different in vivo models, indicates that GPR91 antagonists may have great therapeutic potential in autoimmune disease.

Item Type: Article
Keywords: Allergy, Arthritis, Asthma, GPR91, Immunology, Mast cells, Metabolism, Succinate,
Date Deposited: 13 Oct 2016 00:45
Last Modified: 13 Oct 2016 00:45
URI: https://oak.novartis.com/id/eprint/27765

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