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In-tube Derivatization for the Determination of Absolute Configuration and Enantiomeric Purity of Chiral Compounds by NMR Spectroscopy

Gao, Jinhai and Wang, Bing and Rajan, Srinivasan (2016) In-tube Derivatization for the Determination of Absolute Configuration and Enantiomeric Purity of Chiral Compounds by NMR Spectroscopy. Magn Reson Chem.

Abstract

ABSTRACT We have developed an in-tube derivatization method using commercially available polymer-supported coupling agents to prepare derivatives of chiral compounds directly in NMR tube with high yield and purity. Without requirement of any workup and purificaiton, the method allows quick NMR analysis of chiral compound at micro-sscale level, which is critical for todays’s fast-paced medicinal chemistry efforts in drug discovery. The application of the method was demonstrated for the derivatization of chiral amines, alcohols, diols, aminoa alcohols, thiols and carboxylic acids using various CDAs and coupling agents. This article also serves as a practical guide for in-tube derivatization and selection of suitable chiral derivatizng agents and coupling agents for various types of chiral functional groups.

Item Type: Article
Date Deposited: 25 Apr 2017 00:45
Last Modified: 25 Apr 2017 00:45
URI: https://oak.novartis.com/id/eprint/27295

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