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Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development

Vicini, Paolo and Fields, Owen and Lai, Eric and Litwack, David and Martin, Anne-Marie and Morgan, Thomas and Pacanowski, Michael and Papaluca, Marisa and Perez, Omar and Ringel, Michael and Robson, Matthew and Sakul, Hakan and Vockley, Joseph and Zaks, Tal and Sogaard, Morten (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical Pharmacology and Therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Abstract

High throughput molecular and functional profiling of patients is a key driver of precision medicine. DNA and RNA characterization has been enabled at unprecedented cost and scale through rapid, disruptive progress in sequencing technology, but challenges persist in data management and interpretation. We analyze the state-of-the-art of large-scale unbiased sequencing in drug discovery and development, including technology, application, ethical, regulatory, policy and commercial considerations, and discuss issues of LUS implementation in clinical and regulatory practice.

Item Type: Article
Date Deposited: 22 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:45
URI: https://oak.novartis.com/id/eprint/27258

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