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Bile acids in drug induced liver injury: key players and surrogate markers

Schadt, Heiko and Wolf, Armin and Pognan, Francois and Chibout, Salah-Dine and Merz, Michael and Kullak-Ublick, Gerd (2016) Bile acids in drug induced liver injury: key players and surrogate markers. Clinics and Research in Hepatology and Gastroenterology.

Abstract

Bile acid research has gained great momentum since the role of bile acids as key signaling molecules in the enterohepatic circulation was discovered. Their physiological function in regulating their own homeostasis, as well as energy and lipid metabolism make them interesting targets for the pharmaceutical industry in the context of diseases such as bile acid induced diarrhea, bile acid induced cholestasis or nonalcoholic steatohepatitis. Changes in bile acid homeostasis are also linked to various types of drug-induced liver injury (DILI). However, the key question whether bile acids are surrogate markers for monitoring DILI or key pathogenic players in the onset and progression of DILI is under intense investigation. The purpose of this review is to summarize the different facets of bile acids in the context of normal physiology, hereditary defects of bile acid transport and DILI.

Item Type: Article
Keywords: bile acid, drug induced liver injury, DILI, Cyclosporine A, cholestasis, bile acid transporter
Date Deposited: 27 Apr 2016 23:45
Last Modified: 27 Apr 2016 23:45
URI: https://oak.novartis.com/id/eprint/27251

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