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Trypsin inhibitors for the treatment of pancreatitis

Brandl, Trixi, Simic, Oliver, Skaanderup, Philip, Namoto, Kenji, Berst, Frederic, Ehrhardt, Claus, Schiering, Nikolaus, Mueller, Irene Renate and Woelcke, Julian (2016) Trypsin inhibitors for the treatment of pancreatitis. Bioorganic & Medicinal Chemistry Letters.


Proline-based trypsin inhibitors occupying the S1-S2-S1’ region were identified by an HTS screening campaign. It was discovered that truncation of the P1’ moiety and appropriate extension into the S4 region led to highly potent trypsin inhibitors with excellent selectivity against related serine proteases and a favorable hERG profile

Item Type: Article
Date Deposited: 20 Jul 2016 00:45
Last Modified: 20 Jul 2016 00:45


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