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Systematic Evaluation of Wajima Superposition (Css-MRT) in the Estimation of Human Intravenous Pharmacokinetic Profile

Kim, Sean and La Bonte, Laura and Liang, Guiqing and Berellini, Giuliano and Lombardo, Franco (2016) Systematic Evaluation of Wajima Superposition (Css-MRT) in the Estimation of Human Intravenous Pharmacokinetic Profile. Journal of Pharmacological Science.

Abstract

Synopsis
The prediction of human pharmacokinetics became an integral part of drug development as it helps the planning stage of clinical development, such as the projection of efficacious human dose or optimal dosing paradigm. The objective of this paper is to systematically examine the application of the Wajima’s superposition on a set of 57 compounds, with a balanced representation of metabolically and renally eliminated compounds and diverse chemical space with a wide variety of lipophilicity as well as ionization characters (acid/base). The present work also aims at offering some guidance, and at exploring caveats which may be encountered during the application toward the generation of predicted human i.v. PK profiles.

Item Type: Article
Date Deposited: 26 Apr 2016 23:45
Last Modified: 26 Apr 2016 23:45
URI: https://oak.novartis.com/id/eprint/26613

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