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Natural products as probes in pharmaceutical research

Schmitt, Esther and Hoepfner, Dominic and Krastel, Philipp (2016) Natural products as probes in pharmaceutical research. Journal of Industrial Microbiology and Biotechnology, 43 (2-3). pp. 249-260.

Abstract

From the start of the pharmaceutical research natural products played a key role in drug discovery and development. Over time many discoveries of fundamental new biology were triggered by the unique biological activity of natural products. Unprecedented chemical structures, novel chemotypes, often pave the way to investigate new biology and to explore new pathways and target. This review summarizes the recent results in the area with a focus on research done in the laboratories of Novartis Institutes of BioMedical Research. We aim to put the technological advances in target identification techniques in the context of the current revival of phenotypic screening and the increasingly complex biological questions related to drug discovery.

Item Type: Article
Date Deposited: 25 Apr 2016 23:45
Last Modified: 04 Jul 2016 23:45
URI: https://oak.novartis.com/id/eprint/26259

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