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Diels-Alder Cycloaddition in Medicinal Chemistry

Larraufie, Marie-Helene and Rusch, Marion and Bouchez, Laure (2016) Diels-Alder Cycloaddition in Medicinal Chemistry. Current Organic chemistry - bentham science.

Abstract

Abstract: Diels-Alder reactions have emerged as highly powerful transformations for the generation of structurally complex polycyclic scaffolds essentially due to their associated rapidity and atom-economy. Since its discovery in 1928, a better understanding of steric and electronic effects have allowed the development of many different versions including intra-molecular [4+2] cycloadditions, hetero-Diels-Alder reactions, and catalytic asymmetric variants, among others. In this chapter, we will give an overview on the application of Diels-Alder reactions in Medicinal Chemistry.

Item Type: Article
Date Deposited: 17 May 2016 23:45
Last Modified: 17 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/26139

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