Larraufie, Marie-Helene, Rusch, Marion and Bouchez, Laure (2016) Diels-Alder Cycloaddition in Medicinal Chemistry. Current Organic chemistry - bentham science.

Abstract

Abstract: Diels-Alder reactions have emerged as highly powerful transformations for the generation of structurally complex polycyclic scaffolds essentially due to their associated rapidity and atom-economy. Since its discovery in 1928, a better understanding of steric and electronic effects have allowed the development of many different versions including intra-molecular [4+2] cycloadditions, hetero-Diels-Alder reactions, and catalytic asymmetric variants, among others. In this chapter, we will give an overview on the application of Diels-Alder reactions in Medicinal Chemistry.

Item Type:	Article
Date Deposited:	17 May 2016 23:45
Last Modified:	17 May 2016 23:45
URI:	https://oak.novartis.com/id/eprint/26139