Hurth, Konstanze, Jacquier, Sebastien, Lehmann, Hansjoerg and Wilcken, Rainer (2015) Regioselective nitration of 3-fluoro-2-substituted benzoic acids. Tetrahedron Letters.

Abstract

The preparation of a series of 3-fluoro-2-substituted-6-nitro benzoic acids is described. The partially excellent regioselectivities observed in the nitration step can be rationalized in most cases using Fukui indices of local nucleophilicity.

Item Type:	Article
Keywords:	Regioselective nitration Anthranilic acids Fukui indices Local nucleophilicity
Date Deposited:	13 Oct 2015 13:12
Last Modified:	13 Oct 2015 13:12
URI:	https://oak.novartis.com/id/eprint/24102