Protein production and crystallization at the joint center for structural genomics.
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Lesley, Scott and Wilson, Ian (2005) Protein production and crystallization at the joint center for structural genomics. Journal of Structural and Functional Genomics, 6 (2-3). pp. 71-79. ISSN 1345-711X
Abstract
By definition, structural genomics centers must be able to address a large number of diverse protein targets. The methods developed should permit parallel and cost-effective processing while allowing for the diverse nature of proteins. Our approach to this problem is a multi-tiered effort where targets are characterized and categorized by behavior and processed in parallel by appropriate methods. The Joint Center for Structural Genomics (JCSG) has applied this tactic to create a fully integrated and scaleable structure determination pipeline. Highlights of the development of the current pipeline for protein production and crystallization are presented here.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | high throughput; automated protein production; robotic crystallization; salvage pathways; protein characterization |
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| Date Deposited: | 14 Dec 2009 14:02 |
| Last Modified: | 31 Jan 2013 01:23 |
| URI: | https://oak.novartis.com/id/eprint/240 |