Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
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Peukert, Stefan and Miller-Moslin, Karen (2009) Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics. ChemMedChem, 5 (4). pp. 500-512. ISSN 1860-7187
Official URL: http://www3.interscience.wiley.com/journal/1233198...
Abstract
Review article that provides a general overview of three main topics: 1) the different types of biological assays and in vivo models that have been used for the identification and optimization of Hh inhibitors; 2) Smo inhibitors reported to date, including clinical results where available; 3) efforts toward the identification and characterization of inhibitors of other components of the Hh pathway.
| Item Type: | Article |
|---|---|
| Keywords: | Hedgehog, cancer therapeutics, Smoothened inhibitors, LDE225 |
| Date Deposited: | 13 Oct 2015 13:16 |
| Last Modified: | 13 Oct 2015 13:16 |
| URI: | https://oak.novartis.com/id/eprint/2311 |