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Zebrafish promoter microarrays identify actively transcribed embryonic genes

Wardle, Fiona, Odom, Duncan, Bell, George, Yuan, Bingbing, Danford, Timothy, Wiellette, Elizabeth, Herbolsheimer, Elizabeth, Sive, Hazel, Young, Richard and Smith, James (2006) Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biology, 7 (8). R71. ISSN 1465-6906


We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation with an antibody directed against tri-methylated lysine 4 of Histone H3, we demonstrate the feasibility of this method in zebrafish. This approach will allow investigators to determine the genomic binding locations of DNA interacting proteins during development and expedite the assembly of the genetic networks that regulate embryogenesis.

Item Type: Article
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Additional Information: free final full text version available at publisher's official URL and at PubMedCentral; author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF may be used
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Date Deposited: 13 Oct 2015 13:17
Last Modified: 13 Oct 2015 13:17


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