Translational Repression of Cyclin E Prevents Precocious Mitosis and Embryonic Gene Activation During C. elegans Meiosis
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Biedermann, Bjoern, Wright, Jane, Senften, Mathias, Kalchhauser, Irene, Sarathy, Gautham, Lee, Min-Ho and Ciosk, Rafal (2009) Translational Repression of Cyclin E Prevents Precocious Mitosis and Embryonic Gene Activation During C. elegans Meiosis. Developmental Cell, 17 (3). pp. 355-364. ISSN 1534-5807
Abstract
Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated RNA regulation, the mechanism that normally prevents the loss of germ cell identity remains unexplained. In C. elegans, a teratoma is induced in the absence of the conserved RNA-binding protein GLD-1. Here, we demonstrate that GLD-1 represses translation of CYE-1/cyclin E during meiotic prophase, which prevents germ cells from re-entering mitosis and inducing embryonic-like transcription. We describe a mechanism that prevents precocious mitosis in germ cells undergoing meiosis, propose that this mechanism maintains germ cell identity by delaying the onset of embryonic gene activation until after fertilization, and provide a paradigm for the possible origin of human teratomas.
| Item Type: | Article |
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| Additional Information: | Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | cellcycle |
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| Date Deposited: | 22 Feb 2010 11:49 |
| Last Modified: | 31 Jan 2013 00:47 |
| URI: | https://oak.novartis.com/id/eprint/2226 |