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Key signalling nodes in mammary gland development and cancer: Myc

Hynes, Nancy E. and Stoelzle, Tina (2009) Key signalling nodes in mammary gland development and cancer: Myc. Breast Cancer Research, 11 (5). p. 210. ISSN 1465-5411


ABSTRACT: Myc has been intensely studied since its discovery more than 25 years ago. Insight has been gained into Myc's function in normal physiology, where its role appears to be organ specific, and in cancer where many mechanisms contribute to aberrant Myc expression. Numerous signals and pathways converge on Myc, which in turn acts on a continuously growing number of identified targets, via transcriptional and nontranscriptional mechanisms. This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer.

Item Type: Article
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Additional Information: Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF may be used
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Date Deposited: 22 Feb 2010 11:49
Last Modified: 22 Feb 2010 11:49