Szustakowski, Joseph, Kosinski, Penelope, Marrese, Christine, Lee, Jee, Elliman, Stephen, Nirmala, Nanguneri and Kemp, Daniel (2007) Dynamic resolution of functionally related gene sets in response to acute heat stress. BMC Molecular Biology, 8 (1). p. 46. ISSN 1471-2199

Abstract

BACKGROUND:Using a gene clustering strategy we determined intracellular pathway relationships within skeletal myotubes in response to an acute heat stress stimuli. Following heat shock, the transcriptome was analyzed by microarray in a temporal fashion to characterize the dynamic relationship of signaling pathways.RESULTS:Bioinformatics analyses exposed coordination of functionally-related gene sets, depicting mechanism-based responses to heat shock. Protein turnover-related pathways were significantly affected including protein folding, pre-mRNA processing, mRNA splicing, proteolysis and proteasome-related pathways. Many responses were transient, tending to normalize within 24 hours.CONCLUSION:In summary, we show that the transcriptional response to acute cell stress is largely transient and proteosome-centric.

Item Type:	Article
Related URLs:	http://www.pubmedcentral.nih.gov/article...
Related URLs:	http://www.pubmedcentral.nih.gov/article...
Date Deposited:	13 Oct 2015 13:17
Last Modified:	13 Oct 2015 13:17
URI:	https://oak.novartis.com/id/eprint/219