Design of Two New Chemotypes for Inhibiting the Janus Kinase 2 by Scaffold Morphing
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Furet, Pascal, Gerspacher, Marc and Pissot Soldermann, Carole (2010) Design of Two New Chemotypes for Inhibiting the Janus Kinase 2 by Scaffold Morphing. Bioorganic & Medicinal Chemistry Letters, 20 (6). pp. 1858-1860. ISSN 0960-894X
Official URL: http://dx.doi.org/10.1016/j.bmcl.2010.01.151
Abstract
JAK2 is a target of high interest in chronic myeloproliferative disorders drug research. Starting from a screening hit, two new JAK2 inhibitor chemotypes were designed by scaffold morphing. The prototype compounds of these new series showed nanomolar inhibition of the kinase.
Item Type: | Article |
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Additional Information: | Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
Keywords: | Scaffold morphing; Kinase inhibitor design |
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Date Deposited: | 13 Oct 2015 13:16 |
Last Modified: | 13 Oct 2015 13:16 |
URI: | https://oak.novartis.com/id/eprint/2154 |