Mckeown, Stephen, Charlton, Steven, Cox, Brian, Fitch, Helen, Howson, Christopher, Leblanc, Catherine, Meyer, Arndt, Rosethorne, Elizabeth and Stanley, Emily (2014) Identification of novel IP receptor agonists using historical ligand biased chemical arrays. Bioorganic & medicinal chemistry letters, 24 (10). pp. 2247-2250. ISSN 1464-3405

Abstract

By considering published structural information we have designed high throughput biaryl lipophilic acid arrays leveraging facile chemistry to expedite their synthesis. We rapidly identified multiple hits which were of suitable IP agonist potency. These relatively simple and strategically undecorated molecules present an ideal opportunity for optimization towards our target candidate profile.

Item Type:	Article
Keywords:	Antihypertensive Agents Bridged Bicyclo Compounds High-Throughput Screening Assays Ligands Receptors, Epoprostenol Structure-Activity Relationship
Date Deposited:	04 Jan 2024 00:46
Last Modified:	04 Jan 2024 00:46
URI:	https://oak.novartis.com/id/eprint/21083