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mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

Fendt, Markus and Schmid, Susanne and Thakker, Deepak and Jacobson, Laura and Yamamoto, R and Mitsukawa, Kayo and Maier, Rainer and Natt, Francois and Huesken, Dieter and Kelly, Peter and Mcallister, Kevin and Hoyer, Daniel and Van Der Putten, P. Herman and Cryan, John F. and Flor, Peter Josef (2008) mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity. Molecular Psychiatry, 13 (10). pp. 970-979. ISSN 1476-5578

Abstract

Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates that this receptor may be relevant for the manifestation and treatment of anxiety disorders.

Item Type: Article
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Additional Information: Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: anxiety; fear learning; glutamate; metabotropic glutamate receptors
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Date Deposited: 13 Oct 2015 13:16
Last Modified: 13 Oct 2015 13:16
URI: https://oak.novartis.com/id/eprint/2085

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