Subramanian, Sharadha, Costales, Abran, Poon, Daniel, Shafer, Cynthia and Stuart, Darrin (2014) Design and synthesis of orally bioavailable benzimidazole reverse amides as pan RAF kinase inhibitors. ACS Medicinal Chemistry Letters, 5 (9). pp. 989-992. ISSN 1948-5875

Abstract

Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure-activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

Item Type:	Article
Keywords:	colony stimulating factor-1 receptor CSF1R MAP ras-mitogen activated protein kinase receptor tyrosine kinases RTKs serine threonine kinases STKs TKs tyrosine kinases vascular endothelial growth factor receptor VEGF
Date Deposited:	13 Mar 2018 00:45
Last Modified:	25 Jan 2019 00:46
URI:	https://oak.novartis.com/id/eprint/20560