Azzaoui, Kamal, Hamon, Jacques, Whitebread, Steven and Urban, Laszlo (2010) Bayesian modeling for Predicting Promiscuity and Selectivity of Molecules based on Safety Pharmacology Profiling Data. In: Adverse Side Effect Prediction in Preclinical Drug Discovery. Wiley.

Abstract

‘Promiscuity’ is the likelihood property that a compound is found active against many targets which are not necessary the primary target of interest to develop a safe drug.
Promiscuous compounds can carry various adverse effects liabilities and thus restrict the use of the drug or prevent its entry into the clinic. Therefore, there is a clear interest to evaluate compound promiscuity or selectivity at the earliest possible phase of drug discovery. In some cases, the design of compounds with multiple activities in a given pathway may be desirable.

Item Type:	Book Section
Additional Information:	archiving not allowed on institutional repository
Date Deposited:	14 Dec 2009 13:48
Last Modified:	31 Jan 2013 00:49
URI:	https://oak.novartis.com/id/eprint/1812