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AMPA receptor antagonists: potential therapeutic applications.

Mattes, Henri, Lingenhoehl, Kurt, Kalkman, Hans O., Auberson, Yves, Renaud, Johanne, Schmutz, Markus and Orain, David (2006) AMPA receptor antagonists: potential therapeutic applications. Recent patents on CNS drug discovery, 1 (3). pp. 247-259. ISSN 1574-8898


The current review will focus on the recent patents for AMPA receptor antagonists and their claims, evidence for their therapeutic effectiveness in the treatment of epilepsy and their potential role in psychiatric and neurodegenerative disorders. It will also highlight the proposed mechanisms of action and the implications thereof for our current understanding of the biomolecular basis of these pathologies. It will conclude with a summary of what we know, but also point out the remaining uncertainties, especially as this relates to the claims in the patent under discussion.

Item Type: Article
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Additional Information: Publisher's version/PDF cannot be used
Keywords: AMPA, glutamate, antagonist, epilepsy, schizophrenia, ALS, multiple sclerosis, neuroprotection, anxiety, antiproliferative
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Date Deposited: 14 Dec 2009 14:07
Last Modified: 31 Jan 2013 01:32


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