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Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway.

Stauffer, Frederic, Maira, Sauveur-Michel, Furet, Pascal and García-Echeverría, Carlos (2008) Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 1027-3100. ISSN 1464-3405


Imidazo[4,5-c]quinoline derivatives have been discovered and developed as potent and effective modulators of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) pathway to lead to clinical development candidates. The SAR data of representative examples of this compound class and their biological profiling in cellular and in vivo settings are presented and discussed.

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Date Deposited: 14 Dec 2009 14:04
Last Modified: 31 Jan 2013 01:25