Entry into a new class of protein kinase inhibitors by pseudo ring design.
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Furet, Pascal and Caravatti, Giorgio and Guagnano, Vito and Lang, Marc and Meyer, Thomas and Schoepfer, Joseph (2008) Entry into a new class of protein kinase inhibitors by pseudo ring design. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 897-900. ISSN 1464-3405
Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Abstract
A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.
Item Type: | Article |
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Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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Date Deposited: | 14 Dec 2009 14:04 |
Last Modified: | 14 Dec 2009 14:04 |
URI: | https://oak.novartis.com/id/eprint/175 |