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Entry into a new class of protein kinase inhibitors by pseudo ring design.

Furet, Pascal, Caravatti, Giorgio, Guagnano, Vito, Lang, Marc, Meyer, Thomas and Schoepfer, Joseph (2008) Entry into a new class of protein kinase inhibitors by pseudo ring design. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 897-900. ISSN 1464-3405

Abstract

A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.

Item Type: Article
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Date Deposited: 14 Dec 2009 14:04
Last Modified: 14 Dec 2009 14:04
URI: https://oak.novartis.com/id/eprint/175

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