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Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.

Choi, Ha-Soon and Wang, Zhicheng and Richmond, Wendy and He, Xiaohui and Yang, Kunyong and Jiang, Tao and Sim, Taebo and Karanewsky, Donald and Gu, Xiang-Ju and Zhou, Vicki and Liu, Yi and Ohmori, Osamu and Caldwell, Jeremy and Gray, Nathanael and He, Yun (2006) Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (8). pp. 2173-2176. ISSN 0960-894X

Abstract

A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing)
Keywords: Focal adhesion kinase; Inhibition; 7H-Pyrrolo[2,3-d]pyrimidines; SAR
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Date Deposited: 14 Dec 2009 14:04
Last Modified: 31 Jan 2013 01:25
URI: https://oak.novartis.com/id/eprint/164

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