Le Goff, Benoit, Soltner, Elise, Charrier, Céline, Maugars, Yves, Rédini, Françoise, Heymann, Dominique, Berthelot, Jean-Marie and Gasser, Juerg Andreas (2009) Association of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis. Arthritis Research & Therapy, 11 (6). R185. ISSN 1478-6354

Abstract

Introduction Osteoclasts play a key role in the pathogenesis of
bone erosion and systemic bone mass loss during rheumatoid
arthritis (RA). In this study, we aimed to determine the effect of methotrexate (MTX) and zoledronic acid (ZA), used alone or in combination, on osteoclast-mediated bone erosions and
systemic bone mass loss in a rat model of collagen induced
arthritis (CIA). We hypothesized that MTX and ZA could have an additive effect to prevent both bone erosion and systemic bone loss.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
Keywords:	Rheumatoid arthritis, Animals model, Osteoclast, Methotrexate, Zoledronic acid
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
Date Deposited:	13 Oct 2015 13:16
Last Modified:	13 Oct 2015 13:16
URI:	https://oak.novartis.com/id/eprint/1631