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Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.

Jiang, Tao and Kuhen, Kelli and Wolff, Karen and Yin, Hong and Bieza, Kimberly and Caldwell, Jeremy and Bursulaya, Badry and Tuntland, Tove and Zhang, Kanyin and Karanewsky, Donald and He, Yun (2006) Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2. Bioorganic & Medicinal Chemistry Letters, 16 (8). pp. 2109-2112. ISSN 0960-894X

Abstract

A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing)
Keywords: AIDS; HIV; Reverse transcriptase; Inhibitor; Oxindole; Heterocycle; SAR
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Date Deposited: 14 Dec 2009 14:04
Last Modified: 31 Jan 2013 01:25
URI: https://oak.novartis.com/id/eprint/163

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