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Constitutive activity of muscarinic acetylcholine receptors.

Spalding, Tracy and Burstein, Ethan (2006) Constitutive activity of muscarinic acetylcholine receptors. Journal of receptor and signal transduction research, 26 (1-2). pp. 61-85. ISSN 1079-9893


We review the literature describing constitutive activity of the five muscarinic acetylcholine receptors in native and recombinant systems and discuss the effect of constitutive activity on muscarinic pharmacology in the context of modern models of receptor activation. We include a summary of mutations found to cause constitutive activity and discuss the implications of these data for the structure, function, and activation mechanism of muscarinic receptors. Finally, we discuss the possible physiological significance of constitutive activity of muscarinic receptors, incorporating information provided by targeted deletion of each of the muscarinic subtypes.

Item Type: Article
Related URLs:
Additional Information: author can archive post-print (ie final draft post-refereeing) following 12 month Embargo period; Publisher's version/PDF cannot be used
Keywords: Antagonist; G-protein; GPCR; Inverse agonist; Mutagenesis; Transmembrane
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Date Deposited: 14 Dec 2009 14:04
Last Modified: 31 Jan 2013 01:26


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