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Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.

Wu, Baogen and Kuhen, Kelli and Ngoc Nguyen, Truc and Ellis, David and Anaclerio, Beth and He, Xiaohui and Yang, Kunyong and Karanewsky, Donald and Yin, Hong and Wolff, Karen and Bieza, Kimberly and Caldwell, Jeremy and He, Yun (2006) Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (13). pp. 3430-3433. ISSN 0960-894X

Abstract

The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).

Item Type: Article
Related URLs:
Additional Information: author can archive post-print (ie final draft post-refereeing)
Keywords: Antiviral; HIV; NNRTI; Pyrrolidinone
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Date Deposited: 14 Dec 2009 14:04
Last Modified: 31 Jan 2013 01:26
URI: https://oak.novartis.com/id/eprint/151

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