Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.
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Wu, Baogen, Kuhen, Kelli, Ngoc Nguyen, Truc, Ellis, David, Anaclerio, Beth, He, Xiaohui, Yang, Kunyong, Karanewsky, Donald, Yin, Hong, Wolff, Karen, Bieza, Kimberly, Caldwell, Jeremy and He, Yun (2006) Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (13). pp. 3430-3433. ISSN 0960-894X
Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Abstract
The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing) |
| Keywords: | Antiviral; HIV; NNRTI; Pyrrolidinone |
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| Date Deposited: | 14 Dec 2009 14:04 |
| Last Modified: | 31 Jan 2013 01:26 |
| URI: | https://oak.novartis.com/id/eprint/151 |