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PI3K inhibitors for cancer treatment: where do we stand?

Maira, Sauveur-Michel, Stauffer, Frederic, Schnell, Christian and Garcia-Echeverria, Carlos (2009) PI3K inhibitors for cancer treatment: where do we stand? Biochemical Society Transactions, 37 (Pt 1). pp. 265-272. ISSN 1470-8752


In contrast with cytotoxic agents that do not differentiate between normal proliferating and tumour cells, targeted therapies primarily exert their actions in cancer cells. Initiation and maintenance of tumours are due to genetic alterations in specific loci. The identification of the genes in which these alterations occur has opened new opportunities for cancer treatment. The PI3K (phosphoinositide 3-kinase) pathway is often overactive in human cancers, and various genetic alterations have been found to cause this. In all cases, PI3K inhibition is considered to be one of the most promising targeted therapies for cancer treatment. The present mini-review provides an update on new PI3K inhibitors currently in or entering clinical development. Recent discoveries, challenges and future prospects will be discussed.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); On author's personal web site or institutional repository
Keywords: cancer; mammalian target of rapamycin (mTOR); phosphoinositide 3-kinase (PI3K); small-molecule kinase inhibitor
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Date Deposited: 14 Dec 2009 13:48
Last Modified: 31 Jan 2013 00:53


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