Stability of screening compounds in wet DMSO.
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Engeloch, Caroline, Schopfer, Ulrich, Muckenschnabel, Ingo, Le Goff, Francois, Mees, Herve, Boesch, Karoline and Popov, Maxim (2008) Stability of screening compounds in wet DMSO. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 13 (10). pp. 999-1006. ISSN 1087-0571
Abstract
The impact of storage conditions on compound stability and compound solubility has been debated intensely over the past 5 years. At Novartis, the authors decided to opt for a storage concept that can be considered controversial because they are using a DMSO/water (90/10) mixture as standard solvent. To assess the effect of water in DMSO stocks on compound stability, the authors monitored the purity of a subset of 1404 compounds from ongoing medicinal chemistry projects over several months. The study demonstrated that 85% of the compounds were stable in wet DMSO over a 2-year period at 4 degrees C. This result validates the storage concept developed at Novartis as a pragmatic approach that takes advantage of the benefits of DMSO/water mixtures while mediating the disadvantages. In addition, the authors describe how purity data collected over the course of the chemical validation of high-throughput screening actives are used to improve the analytical quality of the Novartis screening deck.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | compound management ; storage conditions; wet DMSO; high-throughput liquid chromatography/mass spectroscopy (HT LC/MS); quality control (QC) |
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| Date Deposited: | 14 Dec 2009 13:48 |
| Last Modified: | 31 Jan 2013 00:54 |
| URI: | https://oak.novartis.com/id/eprint/1461 |