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TAE226 inhibits human neuroblastoma cell survival.

Beierle, Elizabeth A and Trujillo, Angelica and Nagaram, Abhilasha and Golubovskaya, Vita M and Cance, William G and Kurenova, Elena V (2008) TAE226 inhibits human neuroblastoma cell survival. Cancer Investigation, 26 (2). pp. 145-151. ISSN 1532-4192

Abstract

PURPOSE: Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is a novel small molecule FAK inhibitor. We investigated the effects of TAE226 on neuroblastoma cells in vitro. MATERIALS AND METHODS: Human neuroblastoma cell lines were treated with varying concentrations of TAE226. Following treatment, cell viability, cell cycle, and apoptosis were evaluated. RESULTS: Treatment of human neuroblastoma cell lines with TAE226 resulted in a concentration dependent decrease in FAK phosphorylation, decrease in cellular viability, cell cycle arrest, and an increase in apoptosis. CONCLUSIONS: Targeting FAK provides potential therapeutic options for the treatment of neuroblastoma and deserves further investigation.

Item Type: Article
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Keywords: Neuroblastoma; FAK; TAE226
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Date Deposited: 14 Dec 2009 13:48
Last Modified: 14 Dec 2009 13:48
URI: https://oak.novartis.com/id/eprint/1419

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