TAE226 inhibits human neuroblastoma cell survival.
Beierle, Elizabeth A, Trujillo, Angelica, Nagaram, Abhilasha, Golubovskaya, Vita M, Cance, William G and Kurenova, Elena V (2008) TAE226 inhibits human neuroblastoma cell survival. Cancer Investigation, 26 (2). pp. 145-151. ISSN 1532-4192
Abstract
PURPOSE: Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is a novel small molecule FAK inhibitor. We investigated the effects of TAE226 on neuroblastoma cells in vitro. MATERIALS AND METHODS: Human neuroblastoma cell lines were treated with varying concentrations of TAE226. Following treatment, cell viability, cell cycle, and apoptosis were evaluated. RESULTS: Treatment of human neuroblastoma cell lines with TAE226 resulted in a concentration dependent decrease in FAK phosphorylation, decrease in cellular viability, cell cycle arrest, and an increase in apoptosis. CONCLUSIONS: Targeting FAK provides potential therapeutic options for the treatment of neuroblastoma and deserves further investigation.
Item Type: | Article |
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Additional Information: | self-archiving policy unknown for this publisher |
Keywords: | Neuroblastoma; FAK; TAE226 |
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Date Deposited: | 14 Dec 2009 13:48 |
Last Modified: | 14 Dec 2009 13:48 |
URI: | https://oak.novartis.com/id/eprint/1419 |