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Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance.

Osborn, Olivia and Gram, Hermann and Zorrilla, Eric P and Conti, Bruno and Bartfai, Tamas (2008) Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Medical Weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology, 138 (45-46). pp. 665-673. ISSN 1424-7860

Abstract

Body weight homeostasis is regulated by central and peripheral mechanisms, in which cytokines appear to have an important role.The circulating levels of the cytokines interleukin 1 (IL-1) and interleukin 18 (IL-18), and of inflammatory mediators such as prostaglandin E2 (PGE2), amongst others, are elevated in obese individuals. The low-grade inflammation associated with obesity may contribute to the development of insulin resistance, impaired glucose tolerance and type 2 diabetes. This review highlights results of studies in mice which indicate important roles for these proinflammatory cytokines during the development of obesity and insulin resistance, and in the treatment of type 2 diabetes.

Item Type: Article
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Date Deposited: 14 Dec 2009 13:48
Last Modified: 31 Jan 2013 00:55
URI: https://oak.novartis.com/id/eprint/1359

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