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H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming.

Daujat, Sylvain and Weiss, Thomas and Mohn, Fabio and Lange, Ulrike C and Ziegler-Birling, Celine and Zeissler, Ulrike and Lappe, Michael and Schuebeler, Dirk and Torres-Padilla, Maria-Elena and Schneider, Robert (2009) H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming. Nature Structural & Molecular Biology, 16 (7). pp. 777-781. ISSN 1545-9985

Abstract

Histone modifications are central to the regulation of all DNA-dependent processes. Lys64 of histone H3 (H3K64) lies within the globular domain at a structurally important position. We identify trimethylation of H3K64 (H3K64me3) as a modification that is enriched at pericentric heterochromatin and associated with repeat sequences and transcriptionally inactive genomic regions. We show that this new mark is dynamic during the two main epigenetic reprogramming events in mammals. In primordial germ cells, H3K64me3 is present at the time of specification, but it disappears transiently during reprogramming. In early mouse embryos, it is inherited exclusively maternally; subsequently, the modification is rapidly removed, suggesting an important role for H3K64me3 turnover in development. Taken together, our findings establish H3K64me3 as a previously uncharacterized histone modification that is preferentially localized to repressive chromatin. We hypothesize that H3K64me3 helps to 'secure' nucleosomes, and perhaps the surrounding chromatin, in an appropriately repressed state during development.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 14 Dec 2009 13:49
Last Modified: 31 Jan 2013 00:57
URI: https://oak.novartis.com/id/eprint/1179

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