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L-type voltage-dependent Ca(2+) channels mediate expression of presynaptic LTP in amygdala.

Fourcaudot, Elodie and Gambino, Frederic and Casassus, Guillaume and Poulain, Bernard and Humeau, Yann and Luethi, Andreas (2009) L-type voltage-dependent Ca(2+) channels mediate expression of presynaptic LTP in amygdala. Nature Neuroscience. ISSN 1546-1726

Abstract

The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca(2+) channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC-mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 14 Dec 2009 13:49
Last Modified: 31 Jan 2013 00:58
URI: https://oak.novartis.com/id/eprint/1173

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