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Reaction of Fe3(CO)12 with Octreotide – Chemical, Electrochemical and Biological Investigations

Apfel, Ulf_Peter, Rudolph, Manfred, Apfel, Christina, Robl, Christian, Langenegger, Daniel, Hoyer, Daniel, Jaun, Bernhard, Seebach, Dieter and Weigand, Wolfgang (2010) Reaction of Fe3(CO)12 with Octreotide – Chemical, Electrochemical and Biological Investigations. Dalton Transactions, 39 (12). p. 3065. ISSN 1477-92261477-9234

Official URL: http://10.1039/B921299J

Abstract

In search for peptidic [FeFe] hydrogenase mimics the cyclic disulfide sandostatin® (octreotide) was allowed to react with Fe3(CO)12. An Fe2(CO)6 complex was isolated and characterized spectroscopically and by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H+ to H2. It is suggested by radioligand binding assays that the complex retains ca. 10% of the binding affinity for the GCPRs hsstr1-5 of somatostatin.

Item Type: Article
Keywords: somatostatin, octreotide
Date Deposited: 24 Mar 2016 00:45
Last Modified: 24 Mar 2016 00:45
URI: https://oak.novartis.com/id/eprint/1150

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