Keaney, Erin, Connolly, Michael, Dobler, Markus, Karki, Rajeshri, Honda, Ayako, Sokup, Samantha, Karur, Subramanian, Britt, Shawn, Patnaik, Anup, Raman, Prakash, Hamann, Lawrence, Wiedmann, Brigitte and Lamarche, Matthew (2014) 2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors for the treatment of HCV. Bioorganic and Medicinal Chemistry Letters.

Abstract

Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβleads to potent inhibition of HCV replication as observed in genotype (GT) 1a and 1b replicon and GT2a JFH1 virus assays in vitro.

Item Type:	Article
Date Deposited:	13 Oct 2015 13:13
Last Modified:	13 Oct 2015 13:13
URI:	https://oak.novartis.com/id/eprint/11353