EBF Recommendation for stability testing of anti-drug antibodies; lessons learned from anti-vaccine antibody stability studies.
Pihl, Susanne, Michaut, Lydia, Hendriks, Jenny, Loebbert, Ralph, Ryding, Janka, Nemansky, Martin, Vermet, Laurent and Companjen, Arjen (2014) EBF Recommendation for stability testing of anti-drug antibodies; lessons learned from anti-vaccine antibody stability studies. Bioanalysis, 6 (10). pp. 1409-1413. ISSN 1757-6180
Abstract
Long- and short-term stability testing of the analyte is one of the key parameters in bioanalytical method validation in support of pharmacokinetics. However, for immunogenicity testing the scientific rationale for long- and short-term stability testing on quality control (QC) samples most often spiked with polyclonal antibody raised in a different species should be questioned. Therefore, the European Bioanalysis Forum (EBF) formed a Topic Team (TT) to discuss the scientific rationale for stability testing of anti-drug antibodies (ADA). A review of EBF member companies’ experience on ADA stability and data from vaccine projects was the basis of this discussion. EBF recommends to perform short-term stability testing but not to perform long-term stability testing of ADAs in non-clinical and clinical studies.
Item Type: | Article |
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Keywords: | ADAs (Anti-drug antibodies); Stability testing; Long-term stability: AVAs /Anti-vaccine antibodies) |
Date Deposited: | 13 Oct 2015 13:13 |
Last Modified: | 13 Oct 2015 13:13 |
URI: | https://oak.novartis.com/id/eprint/11011 |