Imaging of a β-Peptide Distribution in Whole-Body Mice Sections by MALDI Mass Spectrometry
Stoeckli, Markus, Staab, Dieter, Schweitzer, Alain, Gardiner, James and Seebach, Dieter (2007) Imaging of a β-Peptide Distribution in Whole-Body Mice Sections by MALDI Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 18 (11). pp. 1921-1924. ISSN 1044-0305
Abstract
Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.
Item Type: | Article |
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Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
Keywords: | TISSUE-SECTIONS; GAMMA-PEPTIDES; STABILITY; PROTEINS |
Date Deposited: | 14 Dec 2009 13:49 |
Last Modified: | 31 Jan 2013 00:59 |
URI: | https://oak.novartis.com/id/eprint/1100 |