Sakaki, Junichi, Kishida, Masashi, Konishi, Kazuhide, Gunji, Hiroki, Toyao, Atsushi, Matsumoto, Yuki, Kanazawa, Takanori, Uchiyama, Hidefumi, Fukaya, Hiroaki, Mitani, Hironobu, Arai, Yoshie and Kimura, Masaaki (2007) Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents. Bioorganic & Medicinal Chemistry Letters, 17 (17). pp. 4804-4807. ISSN 0960-894X

Abstract

A series of diazepinylbenzoic acid derivatives were synthesized and tested in the inhibition assay of the transactivation of RXR. Oral treatment of cyano derivatives (16f) was found to show anti-diabetic and anti-obesity effects in KK-A(y) mice.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	RXR; Antagonist; Anti-diabetic; Anti-obesity
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 14:07
Last Modified:	14 Dec 2009 14:07
URI:	https://oak.novartis.com/id/eprint/11