Efficient preparation of Ellman’s imines from trifluoromethyl ketones promoted by zirconium tert-butoxide
Tools
Kawanami, Toshio, Karns, Alexander, Adams, Christopher and Serrano-Wu, Michael (2013) Efficient preparation of Ellman’s imines from trifluoromethyl ketones promoted by zirconium tert-butoxide. Tetrahedron Letters.
Official URL: http://www.journals.elsevier.com/tetrahedron-lette...
Abstract
Zirconium-mediated imine formation reaction of trifluoromethyl ketones with chiral N-tert-butylsulfinamide is described. The efficiency of this protcol was superior to the standard titanium based procedure especially for sterically demanding trfluoromethyl ketones.
Item Type: | Article |
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Date Deposited: | 13 Oct 2015 13:13 |
Last Modified: | 13 Oct 2015 13:13 |
URI: | https://oak.novartis.com/id/eprint/10854 |