Healy, Mark, Chan, Louis, Poole, Darren, Shen, Di and Donohoe, Timothy (2014) Rhodium-Catalyzed Ketone Alkylation Using Methanol Under Mild Conditions: Formation of Alpha-Branched Products. Angewandte Chemie (International Ed. in English), 53 (3). pp. 761-765. ISSN 14337851

Abstract

We report our findings into the synthesis of α-branched
ketone products by the alkylation of ketones using methanol. Pleasingly we have found that methanol alkylation could be observed at 65 °C,17 indicating that methanol dehydrogenation can be achieved under these mild oxidative conditions, and this represents a convenient method for the use of methanol as a renewable C1-synthetic building block.

Item Type:	Article
Related URLs:	http://pubs.acs.org/journal/jacsat
Keywords:	Rhodium, Catalysis, Methanol
Related URLs:	http://pubs.acs.org/journal/jacsat
Date Deposited:	24 Jun 2016 23:45
Last Modified:	24 Jun 2016 23:45
URI:	https://oak.novartis.com/id/eprint/10844