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The regulation of tenascin expression by tissue microenvironments.

Tucker, Richard P and Chiquet, Ruth (2009) The regulation of tenascin expression by tissue microenvironments. Biochimica et Biophysica Acta, 1793 (5). pp. 888-892. ISSN 0006-3002


Tenascins are a family of four extracellular matrix proteins: tenascin-C, X, R and W. The four members of the family have strikingly diverse patterns of expression during development and in the adult organism indicating independent mechanisms of regulation. In this review we illustrate that there are two types of tenascins, those that are significantly regulated by the tissue microenvironment (tenascin-C and tenascin-W), and those that have stabile, restricted expression patterns (tenascin-R and tenascin-X). We summarize what is known about the regulation of tenascin expression by transforming growth factor betas, fibroblast growth factors, platelet derived growth factors, as well as pro- and anti-inflammatory cytokines or hormones that either induce or inhibit expression of tenascins.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Extracellular matrix; Growth factor; Transforming growth factor beta; Development; Tumor stroma; Fibroblast growth factor
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Date Deposited: 14 Dec 2009 13:49
Last Modified: 31 Jan 2013 01:00


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