Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells.
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Chekulaeva, Marina and Filipowicz, Witold (2009) Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Current Opinion in Cell Biology, 21 (3). pp. 452-460. ISSN 0955-0674
Abstract
MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully understood and different studies have produced often-contradictory results. miRNAs can affect both the translation and stability of mRNAs. In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 14 Dec 2009 13:49 |
| Last Modified: | 31 Jan 2013 01:00 |
| URI: | https://oak.novartis.com/id/eprint/1026 |