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Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.

Hergovich, Alexander and Hemmings, Brian Arthur (2009) Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. BioFactors (Oxford, England). ISSN 0951-6433


The NDR/LATS family of kinases is a subgroup of the AGC group of protein kinases and is conserved from lower eukaryotes to humans. Like other AGC kinases, NDR/LATS kinases require phosphorylation of conserved Ser/Thr residues for activation. On the one hand, binding of the coactivator MOB to NDR/LATS allows autophosphorylation. On the other hand, MST kinases directly phosphorylate NDR/LATS kinases. In addition to our understanding of the molecular activation mechanisms, recent studies have shown that LATS kinases play a central role in Hippo/SWH (Salvador/Warts/Hippo) tumor suppressor pathways, which coordinate cell proliferation and apoptosis by regulating proto-oncogenes, such as YAP and TAZ. In this review, we summarize current knowledge of Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ networks (also termed mammalian Hippo signaling) and their roles in mammalian cellular transformation. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.

Item Type: Article
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Additional Information: archiving not allowed on institutional repository
Keywords: STK38/STK38L; MOB/Mps one binder protein; MST/mammalian serine/threonine sterile 20-like kinase; tumor suppressor/proto-oncogene
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Date Deposited: 14 Dec 2009 13:50
Last Modified: 31 Jan 2013 01:00


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