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The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics.

Parcellier, Arnaud and Tintignac, Lionel and Zhuravleva, Elena and Dummler, Bettina and Brazil, Derek Patrick and Hynx, Deborah and Cron, Peter David and Schenk, Susanne and Olivieri, Vesna and Hemmings, Brian Arthur (2009) The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics. PloS One, 4 (5). e5471. ISSN 1932-6203

Abstract

BACKGROUND: Mitochondria are central to the metabolism of cells and participate in many regulatory and signaling events. They are looked upon as dynamic tubular networks. We showed recently that the Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that may be released into the cytosol under apoptotic conditions. METHODOLOGY/PRINCIPAL FINDINGS: Here we report an unexpected function of CTMP in mitochondrial homeostasis. In this study, both full length CTMP, and a CTMP mutant refractory to N-terminal cleavage and leading to an immature protein promote clustering of spherical mitochondria, suggesting a role for CTMP in the fission process. Indeed, cellular depletion of CTMP led to accumulation of swollen and interconnected mitochondria, without affecting the mitochondrial fusion process. Importantly, in vivo results support the relevance of these findings, as mitochondria from livers of adult CTMP knockout mice had a similar phenotype to cells depleted of CTMP. CONCLUSIONS/SIGNIFICANCE: Together, these results lead us to propose that CTMP has a major function in mitochondrial dynamics and could be involved in the regulation of mitochondrial functions.

Item Type: Article
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Date Deposited: 13 Oct 2015 13:17
Last Modified: 13 Oct 2015 13:17
URI: https://oak.novartis.com/id/eprint/1011

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